Total Syntheses

Class projects demonstrating replacement reactions for total syntheses from published literature, with detailed rationale for each proposed implementation.

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Proposal 1

Rugulovasine A: A SmI₂ Catalyzed Cyclization

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Proposal 2

(-)-Centrolobine: Base-Free Catalytic Wittig Reaction

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Proposal 3

Alectinib: Electrocatalytic Hydrogenation of Terminal Alkyne

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Proposal 4

(+)-Selaginedorffone B: Carbonyl Generation and Electrophotocatalytic Olefination

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