Reaction Substitution Proposals:

Below are four class projects displaying replacement reactions for total syntheses pulled from published literature, with the rationale for implementation defended.

Proposal 1 (Rugulovasine A): A SmI2 Catalzed Cyclization

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Proposal 2 ((-)-Centrolobine): Employing a Base-Free Catalytic Wittig Reaction

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Proposal 3 (Alectinib): Electrocatalytic Hydrogenation of a Terminal Alkyne

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Proposal 4 ((+)-Selaginedorffone B): Carbonyl Generation and Electrophotocatalytic Olefination

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